InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cenpc1

Summary

InnateDB Protein

IDBP-174878.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cenpc1

Protein Name

centromere protein C1

Synonyms

CENP-C; Cenpc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031170

InnateDB Gene

IDBG-174876 (Cenpc1)

Protein Structure

UniProt Annotation

Function

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019237	centromeric DNA binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0051382	kinetochore assembly

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000780	condensed nuclear chromosome, centromeric region
GO:0005634	nucleus
GO:0005721	centromeric heterochromatin
GO:0005737	cytoplasm