InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gcdh

Summary

InnateDB Protein

IDBP-175139.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gcdh

Protein Name

glutaryl-Coenzyme A dehydrogenase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003907

InnateDB Gene

IDBG-175137 (Gcdh)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor.

Subcellular Localization

Mitochondrion matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003995	acyl-CoA dehydrogenase activity
GO:0004361	glutaryl-CoA dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006568	tryptophan metabolic process
GO:0006637	acyl-CoA metabolic process
GO:0008152	metabolic process
GO:0019395	fatty acid oxidation
GO:0046949	fatty-acyl-CoA biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:104541

InterPro

IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR013107 Acyl-CoA dehydrogenase, type 2, C-terminal
IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal

PFAM

PF02770
PF00441
PF08028
PF02771

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q60759