Version 5.4
Mus musculus Protein: Gnrhr
Summary
InnateDB Protein IDBP-175202.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gnrhr
Protein Name gonadotropin releasing hormone receptor
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000031172
InnateDB Gene IDBG-175200 (Gnrhr)
Protein Structure
UniProt Annotation
Function Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Pituitary gland.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004968 gonadotropin-releasing hormone receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0097211 cellular response to gonadotropin-releasing hormone
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:95790
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001658 Gonadotrophin-releasing hormone receptor family
IPR001817 Vasopressin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR00529
PR00896
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q01776
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14715
UniGene Mm.26791
RefSeq NP_034453
MGI ID
MGI Symbol Gnrhr
OMIM
CCDS CCDS19379
HPRD
IMGT
EMBL L01119 L33778 L33788 L33789 M93108
GenPept AAA37716 AAB59636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca