Version 5.4
| Mus musculus Gene: Gnrhr | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-175200.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Gnrhr | ||||||
| Gene Name | gonadotropin releasing hormone receptor | ||||||
| Synonyms | |||||||
| Species | Mus musculus | ||||||
| Ensembl Gene | ENSMUSG00000029255 | ||||||
| Encoded Proteins |
gonadotropin releasing hormone receptor
gonadotropin releasing hormone receptor
gonadotropin releasing hormone receptor
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109163:
This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008] This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5\' region and multiple polyA signals in the 3\' region have been identified for this gene. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 5:86180754-86197901 | ||||||
| Strand | Reverse strand | ||||||
| Band | E1 | ||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||
| NETPATH | |||||||
| REACTOME |
GPCR downstream signaling pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Hormone ligand-binding receptors pathway
GPCR ligand binding pathway
G alpha (q) signalling events pathway
Signal Transduction pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
GnRH signaling pathway pathway
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| INOH | |||||||
| PID NCI | |||||||
| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH | |||||||
| REACTOME |
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Hormone ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Signaling by GPCR pathway
Signal Transduction pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
Hormone ligand-binding receptors pathway
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| KEGG |
GnRH signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||
| PID NCI | |||||||
| Cross-References | |||||||
| SwissProt | Q01776 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 14715 | ||||||
| UniGene | Mm.26791 | ||||||
| RefSeq | NM_010323 XM_006534795 | ||||||
| OMIM | |||||||
| CCDS | CCDS19379 | ||||||
| HPRD | |||||||
| IMGT | |||||||
| MGI ID | MGI:95790 | ||||||
| MGI Symbol | Gnrhr | ||||||
| EMBL | L01119 L33778 L33788 L33789 M93108 | ||||||
| GenPept | AAA37716 AAB59636 | ||||||
| RNA Seq Atlas | 14715 | ||||||