InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hspa1a

Summary

InnateDB Protein

IDBP-175334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hspa1a

Protein Name

heat shock protein 1A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084586

InnateDB Gene

IDBG-606688 (Hspa1a)

Protein Structure

UniProt Annotation

Function

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	1 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0000902	cell morphogenesis
GO:0006402	mRNA catabolic process
GO:0006950	response to stress
GO:0006986	response to unfolded protein
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0045087	innate immune response

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:96244

InterPro

IPR004753 Cell shape determining protein MreB/Mrl
IPR013126 Heat shock protein 70 family
IPR029047 Heat shock protein 70kD, peptide-binding domain
IPR029048 Heat shock protein 70kD, C-terminal domain

PFAM

PF06723
PF00012

PRINTS

PR01652
PR00301

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61696