InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ap3d1

Summary

InnateDB Protein

IDBP-175530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap3d1

Protein Name

adaptor-related protein complex 3, delta 1 subunit

Synonyms

AA407035; Ap3d; Bolvr; mBLVR1; mh; mocha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020420

InnateDB Gene

IDBG-175528 (Ap3d1)

Protein Structure

UniProt Annotation

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. {ECO:0000250, ECO:0000269PubMed:21998198}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0008565	protein transporter activity

Biological Process

GO:0006829	zinc ion transport
GO:0006886	intracellular protein transport
GO:0008089	anterograde axon cargo transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0019882	antigen processing and presentation
GO:0033365	protein localization to organelle
GO:0035646	endosome to melanosome transport
GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048490	anterograde synaptic vesicle transport
GO:0048499	synaptic vesicle membrane organization
GO:0051138	positive regulation of NK T cell differentiation
GO:0061088	regulation of sequestering of zinc ion
GO:0072657	protein localization to membrane

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030424	axon
GO:0043195	terminal bouton

Protein Structure and Domains

PDB ID

MGI:107734

InterPro

IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR010474 Bovine leukaemia virus receptor
IPR016024 Armadillo-type fold
IPR017105 Adaptor protein complex AP-3, delta subunit

PFAM

PF01602
PF06375

PRINTS

PIRSF

PIRSF037092

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O54774