InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ap3d1

Summary

InnateDB Gene

IDBG-175528.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ap3d1

Gene Name

adaptor-related protein complex 3, delta 1 subunit

Synonyms

AA407035; Ap3d; Bolvr; mBLVR1; mh; mocha

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020198

Encoded Proteins

IDBP-175530

adaptor-related protein complex 3, delta 1 subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065000:
The protein encoded by this gene is a subunit of the AP3 adaptor-like complex, which is not clathrin-associated, but is associated with the golgi region, as well as more peripheral structures. The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and may be directly involved in trafficking to lysosomes. This subunit is implicated in intracellular biogenesis and trafficking of pigment granules, and possibly platelet dense granules and neurotransmitter vesicles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80706978-80742211

Strand

Reverse strand

Band

Transcripts

ENSMUST00000020420

ENSMUSP00000020420

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0008565	protein transporter activity

Biological Process

GO:0006829	zinc ion transport
GO:0006886	intracellular protein transport
GO:0008089	anterograde axon cargo transport
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0019882	antigen processing and presentation
GO:0033365	protein localization to organelle
GO:0035646	endosome to melanosome transport
GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0048490	anterograde synaptic vesicle transport
GO:0048499	synaptic vesicle membrane organization
GO:0051138	positive regulation of NK T cell differentiation
GO:0061088	regulation of sequestering of zinc ion
GO:0072657	protein localization to membrane

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005802	trans-Golgi network
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030424	axon
GO:0043195	terminal bouton

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000065000

View Gene Order

ENSBTAG00000009034

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04142

Lysosome pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04142

Lysosome pathway

INOH

PID NCI

Cross-References

SwissProt

O54774

TrEMBL

Q3U1P6 Q3U237 Q3UR54 Q80T04

UniProt Splice Variant

Entrez Gene

11776

UniGene

Mm.209294

RefSeq

NM_007460 XM_006513141

OMIM

CCDS

CCDS35984

HPRD

IMGT

MGI ID

MGI:107734

MGI Symbol

Ap3d1

EMBL

AB004305 AF469668 AF469669 AK141789 AK155518 AK155825 BC048786 BC053066

GenPept

AAH48786 AAH53066 AAO40830 BAA24578 BAE24834 BAE33305 BAE33449

RNA Seq Atlas

11776