InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sp110

Summary

InnateDB Protein

IDBP-175536.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sp110

Protein Name

Sp110 nuclear body protein

Synonyms

5031415C07Rik; 52kDa; 5830484A20Rik; ENSMUSG00000075603; Ifi75; Ipr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091226

InnateDB Gene

IDBG-175534 (Sp110)

Protein Structure

UniProt Annotation

Function

May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells. {ECO:0000269PubMed:15815631}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00185, ECO:0000255PROSITE-ProRule:PRU00747}.

Disease Associations

Note=Defects in Sp110 are a cause of severely impaired resistance to infection by M.tuberculosis. {ECO:0000269PubMed:15815631}.

Tissue Specificity

Detected in lung and macrophages. {ECO:0000269PubMed:15815631}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0009617	response to bacterium
GO:0043065	positive regulation of apoptotic process
GO:0045087	innate immune response