InnateDB Protein
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IDBP-175572.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dpysl2
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Protein Name
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dihydropyrimidinase-like 2
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Synonyms
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AI851130; Crmp2; DRP2; Musunc33; TOAD-64; Ulip2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022629
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InnateDB Gene
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IDBG-175570 (Dpysl2)
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Protein Structure
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Function |
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. {ECO:0000269PubMed:22057101}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}. Note=Tightly but non-covalently associated with membranes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0016787
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hydrolase activity
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GO:0016810
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
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GO:0016812
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
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GO:0019901
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protein kinase binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1349763
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InterPro |
IPR006680
Amidohydrolase 1
IPR011059
Metal-dependent hydrolase, composite domain
IPR011778
Hydantoinase/dihydropyrimidinase
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PFAM |
PF01979
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O08553
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PhosphoSite |
PhosphoSite-O08553
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12934
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UniGene |
Mm.475100
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RefSeq |
NP_034085
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MGI ID |
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MGI Symbol |
Dpysl2
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OMIM |
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CCDS |
CCDS27224
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HPRD |
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IMGT |
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EMBL |
BC062955
Y10339
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GenPept |
AAH62955
CAA71370
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