InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxd2

Summary

InnateDB Protein

IDBP-175584.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxd2

Protein Name

forkhead box D2

Synonyms

AI426778; Mf2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066868

InnateDB Gene

IDBG-175582 (Foxd2)

Protein Structure

UniProt Annotation

Function

Probable transcription factor involved in embryogenesis and somatogenesis. {ECO:0000269PubMed:9510020}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed at high levels in the ventral region of newly formed somites, in sclerotomal derivatives, in lateral plate and cephalic mesoderm and in the first and second branchial arches. Other regions of mesodermal expression include the developing tongue, meninges, nose, whiskers, kidney, genital tubercule and limb joints. In the nervous system it is transcribed in restricted regions of the mid- and forebrain. {ECO:0000269PubMed:9510020}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001755	neural crest cell migration
GO:0001822	kidney development
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0007422	peripheral nervous system development
GO:0030318	melanocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048484	enteric nervous system development
GO:0048485	sympathetic nervous system development
GO:0048846	axon extension involved in axon guidance
GO:0048937	lateral line nerve glial cell development
GO:0050935	iridophore differentiation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity
GO:0051216	cartilage development