InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk39

Summary

InnateDB Protein

IDBP-175592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk39

Protein Name

serine/threonine kinase 39, STE20/SPS1 homolog (yeast)

Synonyms

AW227544; AW556857; DCHT; RF005; Rnl5; SPAK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099776

InnateDB Gene

IDBG-175590 (Stk39)

Protein Structure

UniProt Annotation

Function

May act as a mediator of stress-activated signals.

Subcellular Localization

Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Nucleus when caspase-cleaved. {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0018107	peptidyl-threonine phosphorylation
GO:0023014	signal transduction by phosphorylation
GO:0035556	intracellular signal transduction
GO:0043268	positive regulation of potassium ion transport
GO:0050727	regulation of inflammatory response
GO:0071476	cellular hypotonic response
GO:1901017	negative regulation of potassium ion transmembrane transporter activity
GO:1901380	negative regulation of potassium ion transmembrane transport
GO:2000681	negative regulation of rubidium ion transport
GO:2000687	negative regulation of rubidium ion transmembrane transporter activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:1858416

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain

PFAM

PF00069
PF07714
PF12202

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt