InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HRH4

Summary

InnateDB Protein

IDBP-1756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HRH4

Protein Name

histamine receptor H4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000256906

InnateDB Gene

IDBG-1754 (HRH4)

Protein Structure

UniProt Annotation

Function

The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). {ECO:0000269PubMed:12503632}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node. {ECO:0000269PubMed:12503632}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004969	histamine receptor activity

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008150	biological_process
GO:0043408	regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR008102 Histamine H4 receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01726

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9H3N8