Version 5.4
| Homo sapiens Gene: HRH4 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Gene | IDBG-1754.6 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | HRH4 | ||||||||||||
| Gene Name | histamine receptor H4 | ||||||||||||
| Synonyms | |||||||||||||
| Species | Homo sapiens | ||||||||||||
| Ensembl Gene | ENSG00000134489 | ||||||||||||
| Encoded Proteins |
histamine receptor H4
histamine receptor H4
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
| InnateDB Annotation | |||||||||||||
| Summary |
HRH4 is a histamine receptor that can mediate cytokine production (e.g. IL6) from mast cells. HRH4 is also able to synergize with other inflammatory signals, such as LPS, to potentiate cytokine production and contribute to inflammation. (Demonstrated in murine model)
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| InnateDB Annotation from Orthologs | |||||||||||||
| Summary |
[Mus musculus] Hrh4 is a histamine receptor that can mediate cytokine production (e.g. Il6) from mast cells. Hrh4 is also able to synergize with other inflammatory signals, such as LPS, to potentiate cytokine production and contribute to inflammation.
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| Entrez Gene | |||||||||||||
| Summary |
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
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| Gene Information | |||||||||||||
| Type | Protein coding | ||||||||||||
| Genomic Location | Chromosome 18:24460629-24479957 | ||||||||||||
| Strand | Forward strand | ||||||||||||
| Band | q11.2 | ||||||||||||
| Transcripts |
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| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||
| NETPATH | |||||||||||||
| REACTOME |
G alpha (i) signalling events pathway
Histamine receptors pathway
Amine ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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| KEGG |
Neuroactive ligand-receptor interaction pathway
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| INOH | |||||||||||||
| PID NCI | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q9H3N8 | ||||||||||||
| TrEMBL | |||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 59340 | ||||||||||||
| UniGene | Hs.287388 | ||||||||||||
| RefSeq | NM_001143828 NM_001160166 NM_021624 | ||||||||||||
| HUGO | HGNC:17383 | ||||||||||||
| OMIM | 606792 | ||||||||||||
| CCDS | CCDS45841 CCDS11887 | ||||||||||||
| HPRD | 06004 | ||||||||||||
| IMGT | |||||||||||||
| EMBL | AB044934 AB045370 AC007922 AF307973 AF312230 AF325356 AF329449 AJ298292 AY136745 BC069136 BC112348 CH471088 DQ835186 EF444982 | ||||||||||||
| GenPept | AAG32052 AAH69136 AAI12349 AAK12081 AAK43542 AAL01684 AAN01271 ABI54174 ACA05997 BAB13698 BAB20091 CAC83493 EAX01189 | ||||||||||||
| RNA Seq Atlas | 59340 | ||||||||||||