InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plekhf1

Summary

InnateDB Protein

IDBP-175600.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plekhf1

Protein Name

pleckstrin homology domain containing, family F (with FYVE domain) member 1

Synonyms

1810013P09Rik; APPD; LAPF; PHAFIN1; ZFYVE15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096113

InnateDB Gene

IDBG-175598 (Plekhf1)

Protein Structure

UniProt Annotation

Function

May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16188880}. Cytoplasm, perinuclear region {ECO:0000269PubMed:16188880}. Lysosome {ECO:0000269PubMed:16188880}. Note=Translocates to lysosome during apoptosis.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:16188880}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0010314	phosphatidylinositol-5-phosphate binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0046872	metal ion binding
GO:0070273	phosphatidylinositol-4-phosphate binding

Biological Process

GO:0006915	apoptotic process
GO:0007032	endosome organization
GO:0010508	positive regulation of autophagy
GO:0016050	vesicle organization
GO:0046902	regulation of mitochondrial membrane permeability
GO:0072659	protein localization to plasma membrane
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway