InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prdx2

Summary

InnateDB Protein

IDBP-175632.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdx2

Protein Name

peroxiredoxin 2

Synonyms

AL022839; Band-8; NkefB; PRP; PrxII; Tdpx1; TDX1; Torin; TPx; TPx-B; TR; TSA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005292

InnateDB Gene

IDBG-175630 (Prdx2)

Protein Structure

UniProt Annotation

Function

Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in bone marrow. High levels also found in heart, brain, kidney and skeletal muscle. Lower levels in liver, lung and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005515	protein binding
GO:0008379	thioredoxin peroxidase activity
GO:0008430	selenium binding
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity
GO:0051920	peroxiredoxin activity

Biological Process

GO:0000187	activation of MAPK activity
GO:0002536	respiratory burst involved in inflammatory response
GO:0006979	response to oxidative stress
GO:0010310	regulation of hydrogen peroxide metabolic process
GO:0019430	removal of superoxide radicals
GO:0030194	positive regulation of blood coagulation
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032496	response to lipopolysaccharide
GO:0042098	T cell proliferation
GO:0042743	hydrogen peroxide metabolic process
GO:0042744	hydrogen peroxide catabolic process
GO:0045581	negative regulation of T cell differentiation
GO:0048538	thymus development
GO:0048872	homeostasis of number of cells
GO:0055114	oxidation-reduction process
GO:2000378	negative regulation of reactive oxygen species metabolic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:109486

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR012336 Thioredoxin-like fold
IPR013740 Redoxin
IPR019479 Peroxiredoxin, C-terminal

PFAM