InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hook2

Summary

InnateDB Protein

IDBP-175698.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hook2

Protein Name

hook homolog 2 (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000067752

InnateDB Gene

IDBG-175696 (Hook2)

Protein Structure

UniProt Annotation

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:17140400}. Cytoplasm {ECO:0000269PubMed:17140400}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:17140400}. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in brain, cerebellum, kidney, liver and heart, with highest levels in heart and kidney (at protein level). {ECO:0000269PubMed:17140400}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0042802	identical protein binding

Biological Process

GO:0007032	endosome organization
GO:0007040	lysosome organization
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0045022	early endosome to late endosome transport