Version 5.4
Mus musculus Gene: Hook2
Summary
InnateDB Gene IDBG-175696.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hook2
Gene Name hook homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000052566
Encoded Proteins
IDBP-175698
hook homolog 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095066:
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:84990595-85003364
Strand Forward strand
Band C3
Transcripts
ENSMUST00000064495 ENSMUSP00000067752
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
Biological Process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005813 centrosome
GO:0005874 microtubule
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000095066
View Gene Order
ENSBTAG00000008654
Not yet available
Cross-References
SwissProt Q7TMK6
TrEMBL Q3TKK8
UniProt Splice Variant
Entrez Gene 170833
UniGene
RefSeq NM_001167991 NM_133255 XM_006530743
OMIM
CCDS CCDS22489
HPRD
IMGT
MGI ID MGI:2181664
MGI Symbol Hook2
EMBL AK042048 AK145768 AK166954 AK169073 BC002226 BC019486 BC026609 BC055881 BC080744
GenPept AAH02226 AAH19486 AAH26609 AAH55881 AAH80744 BAC31143 BAE26639 BAE39137 BAE40859
RNA Seq Atlas 170833

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca