Version 5.4
Mus musculus Protein: Ppp2r2a
Summary
InnateDB Protein IDBP-175800.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2r2a
Protein Name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
Synonyms 2410004D02Rik; mKIAA1541;
Species Mus musculus
Ensembl Protein ENSMUSP00000086640
InnateDB Gene IDBG-175798 (Ppp2r2a)
Protein Structure
UniProt Annotation
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007165 signal transduction
GO:0043278 response to morphine
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Protein Structure and Domains
PDB ID MGI:1919228
InterPro IPR000009 Protein phosphatase 2A, regulatory subunit PR55
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS PR00600
PIRSF PIRSF037309
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6P1F6
PhosphoSite PhosphoSite-Q6P1F6
TrEMBL Q571J7
UniProt Splice Variant
Entrez Gene 71978
UniGene Mm.474633
RefSeq NP_082308
MGI ID
MGI Symbol Ppp2r2a
OMIM
CCDS CCDS56967
HPRD
IMGT
EMBL AK161507 AK161704 AK164497 AK167189 AK220192 BC065100 BC080692 CH466535
GenPept AAH65100 AAH80692 BAD90377 BAE36431 BAE36540 BAE37812 BAE39320 EDL35982

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca