Version 5.4
Mus musculus Gene: Ppp2r2a
Summary
InnateDB Gene IDBG-175798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp2r2a
Gene Name protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
Synonyms 2410004D02Rik; mKIAA1541
Species Mus musculus
Ensembl Gene ENSMUSG00000022052
Encoded Proteins
IDBP-175800
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000221914:
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:67014057-67072471
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000089230 ENSMUSP00000086640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0007165 signal transduction
GO:0043278 response to morphine
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000221914
View Gene Order
ENSBTAG00000018317
Not yet available
Pathways
NETPATH
REACTOME
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_260005
G1 Phase pathway
REACT_208002
Nuclear Envelope Reassembly pathway
REACT_188804
Cell Cycle pathway
REACT_198522
Nonsense-Mediated Decay (NMD) pathway
REACT_241408
M Phase pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_198528
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_206803
Cyclin A/B1 associated events during G2/M transition pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_233572
Gene Expression pathway
REACT_210180
Initiation of Nuclear Envelope Reformation pathway
REACT_202512
Mitotic Anaphase pathway
KEGG
mmu04530
Tight junction pathway
mmu03015
mRNA surveillance pathway pathway
mmu05160
Hepatitis C pathway
mmu05142
Chagas disease (American trypanosomiasis) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_1857
Cyclin A/B1 associated events during G2/M transition pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_1590
G1 Phase pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_2203
G2/M Transition pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_71
Gene Expression pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04530
Tight junction pathway
hsa05142
Chagas disease (American trypanosomiasis) pathway
hsa03015
mRNA surveillance pathway pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
erbb1_downstream_pathway
ErbB1 downstream signaling
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt Q6P1F6
TrEMBL Q3TPC5 Q3TT94 Q571J7
UniProt Splice Variant
Entrez Gene 71978
UniGene Mm.273997 Mm.391611 Mm.403802 Mm.408659 Mm.474633
RefSeq NM_001205188 NM_028032 XM_006519589
OMIM
CCDS CCDS56967
HPRD
IMGT
MGI ID MGI:1919228
MGI Symbol Ppp2r2a
EMBL AK161507 AK161704 AK164497 AK167189 AK220192 BC065100 BC080692 CH466535
GenPept AAH65100 AAH80692 BAD90377 BAE36431 BAE36540 BAE37812 BAE39320 EDL35982
RNA Seq Atlas 71978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca