Mus musculus Protein: Mta1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-175874.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Mta1 | ||||||||||||||||||||||
Protein Name | metastasis associated 1 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000009099 | ||||||||||||||||||||||
InnateDB Gene | IDBG-175870 (Mta1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. {ECO:0000269PubMed:17671180, ECO:0000269PubMed:19805145, ECO:0000269PubMed:19837670, ECO:0000269PubMed:20071335, ECO:0000269PubMed:20519513, ECO:0000269PubMed:20682799, ECO:0000269PubMed:21965678, ECO:0000269PubMed:24089055}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Nucleus envelope {ECO:0000255PROSITE-ProRule:PRU00512, ECO:0000255PROSITE- ProRule:PRU00624}. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with microtubules. Primarily localized in the cytoplasm in embryonic tissues. Localization at the nuclear envelope is TPR-dependent. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Widely expressed but not in skeletal muscle. Highly expressed in the brain, liver, kidney and cardiac muscle and in mammary tumors. {ECO:0000269PubMed:16617102, ECO:0000269PubMed:24970816}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:2150037 | ||||||||||||||||||||||
InterPro |
IPR000679
Zinc finger, GATA-type IPR000949 ELM2 domain IPR001005 SANT/Myb domain IPR001025 Bromo adjacent homology (BAH) domain IPR009057 Homeodomain-like |
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PFAM |
PF00320
PF01448 PF00249 PF01426 |
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PRINTS |
PR00619
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PIRSF | |||||||||||||||||||||||
SMART |
SM00401
SM00717 SM00439 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q8K4B0 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q8K4B0 | ||||||||||||||||||||||
TrEMBL | M1VMF6 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 116870 | ||||||||||||||||||||||
UniGene | Mm.490261 | ||||||||||||||||||||||
RefSeq | XP_006515481 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Mta1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB039744 AB794093 AB794101 AF288137 AF450245 AF463504 | ||||||||||||||||||||||
GenPept | AAK83044 AAM97587 AAM97588 BAC57413 BAM86004 BAM86012 | ||||||||||||||||||||||