InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mta1

Summary

InnateDB Gene

IDBG-175870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mta1

Gene Name

metastasis associated 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021144

Encoded Proteins

IDBP-175872

metastasis associated 1

IDBP-175874

metastasis associated 1

IDBP-261772

metastasis associated 1

IDBP-261774

metastasis associated 1

IDBP-261776

metastasis associated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20699220

Mta1 binds to the Myd88 promoter to regulate LPS-induced NFkappa B signaling via Myd88-dependent signalling in murine macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 20699220

[Homo sapiens] MTA1 binds to the MYD88 promoter to regulate LPS-induced NFkappa B signaling via MYD88-dependent signalling in murine macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182979:
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:113098278-113137206

Strand

Forward strand

Band

Transcripts

ENSMUST00000069690	ENSMUSP00000064338
ENSMUST00000009099	ENSMUSP00000009099
ENSMUST00000109727	ENSMUSP00000105349
ENSMUST00000109726	ENSMUSP00000105348
ENSMUST00000109723	ENSMUSP00000105345
ENSMUST00000130926
ENSMUST00000134488
ENSMUST00000156030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	34 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001103	RNA polymerase II repressing transcription factor binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0033363	secretory granule organization
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0016581	NuRD complex
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000182979

View Gene Order

ENSBTAG00000047606

Not yet available

Pathways

NETPATH

REACTOME

REACT_245058

RNA Polymerase I Transcription pathway

REACT_244415

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_218274

Chromatin organization pathway

REACT_202766

Chromatin modifying enzymes pathway

REACT_233572

Gene Expression pathway

REACT_257106

HDACs deacetylate histones pathway

REACT_240511

RNA Polymerase I Promoter Clearance pathway

REACT_235780

RNA Polymerase I Transcription Initiation pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_953

RNA Polymerase I Transcription Initiation pathway

REACT_1309

RNA Polymerase I Transcription pathway

REACT_1974

RNA Polymerase I Promoter Clearance pathway

REACT_228222

HDACs deacetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

Q8K4B0

TrEMBL

M1VHG1 M1VMF6

UniProt Splice Variant

Entrez Gene

116870

UniGene

Mm.490261

RefSeq

XM_006515420 XM_006515422 XM_006515424 XM_006536316 XM_006536319 XM_006536320 NM_054081 XM_006515425 XM_006515426 XM_006515427 XM_006515428 XM_006515429 XM_006515430 XM_006515431 XM_006536321 XM_006536322 XM_006536323 XM_006536324 XM_006536325 XM_006536326 XM_006536327

OMIM

CCDS

CCDS36574

HPRD

IMGT

MGI ID

MGI:2150037

MGI Symbol

Mta1

EMBL

AB039744 AB794093 AB794101 AF288137 AF450245 AF463504

GenPept

AAK83044 AAM97587 AAM97588 BAC57413 BAM86004 BAM86012

RNA Seq Atlas

116870