InnateDB Protein
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IDBP-1759.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MED15
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Protein Name
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mediator complex subunit 15
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000263205
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InnateDB Gene
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IDBG-1757 (MED15)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269PubMed:12167862, ECO:0000269PubMed:16630888, ECO:0000269PubMed:16799563}.
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Subcellular Localization |
Cytoplasm. Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney. {ECO:0000269PubMed:11024300}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
75
[view]
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Protein-Protein |
74
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0005515
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protein binding
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Biological Process |
GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0010467
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gene expression
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GO:0019827
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stem cell maintenance
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Cellular Component |
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PDB ID |
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InterPro |
IPR019087
Mediator complex, subunit Med15, metazoa
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PFAM |
PF09606
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96RN5
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PhosphoSite |
PhosphoSite-Q96RN5
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TrEMBL |
Q69YK5
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UniProt Splice Variant |
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Entrez Gene |
51586
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UniGene |
Hs.517421
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RefSeq |
NP_001003891
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HUGO |
HGNC:14248
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OMIM |
607372
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CCDS |
CCDS33602
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HPRD |
12117
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IMGT |
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EMBL |
AC004033
AC005500
AC007050
AC007731
AF056191
AF328769
AK074268
AK090465
AK124925
AK297284
AL832923
BC007529
BC013985
CH471176
CR456537
U80745
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GenPept |
AAB91443
AAC12944
AAH07529
AAH13985
AAK58423
BAB85034
BAC03446
BAG54113
BAG59755
CAG30423
CAH10623
EAX02951
EAX02952
EAX02954
EAX02956
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