Version 5.4
Mus musculus Protein: Nostrin
Summary
InnateDB Protein IDBP-175950.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nostrin
Protein Name nitric oxide synthase trafficker
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036923
InnateDB Gene IDBG-175946 (Nostrin)
Protein Structure
UniProt Annotation
Function Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:15596140}. Nucleus {ECO:0000269PubMed:15596140}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050999 regulation of nitric-oxide synthase activity
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID MGI:3606242
InterPro IPR001060 FCH domain
IPR001452 SH3 domain
IPR011072 HR1 rho-binding repeat
IPR011511 Variant SH3 domain
IPR013315 Spectrin alpha chain, SH3 domain
PFAM PF00611
PF00018
PF14604
PF02185
PF07653
PRINTS PR00452
PR01887
PIRSF
SMART SM00055
SM00326
SM00742
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6WKZ7
PhosphoSite PhosphoSite-Q6WKZ7
TrEMBL
UniProt Splice Variant
Entrez Gene 329416
UniGene Mm.90047
RefSeq NP_853525
MGI ID
MGI Symbol Nostrin
OMIM
CCDS CCDS16087
HPRD
IMGT
EMBL AJ564264 AK052926 AL929221 AY280963 BC069942
GenPept AAH69942 AAP32311 BAC35204 CAD91927 CAM24122

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca