Version 5.4
Mus musculus Gene: Nostrin
Summary
InnateDB Gene IDBG-175946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nostrin
Gene Name nitric oxide synthase trafficker
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000034738
Encoded Proteins
IDBP-175950
nitric oxide synthase trafficker
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163072:
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:69135800-69189330
Strand Forward strand
Band C2
Transcripts
ENSMUST00000041865 ENSMUSP00000036923
ENSMUST00000141276
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050999 regulation of nitric-oxide synthase activity
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163072
View Gene Order
ENSBTAG00000010362
Not yet available
Pathways
NETPATH
REACTOME
REACT_204801
eNOS activation and regulation pathway
REACT_215995
NOSTRIN mediated eNOS trafficking pathway
REACT_188937
Metabolism pathway
REACT_208364
Metabolism of nitric oxide pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6WKZ7
TrEMBL
UniProt Splice Variant
Entrez Gene 329416
UniGene Mm.90047
RefSeq NM_181547
OMIM
CCDS CCDS16087
HPRD
IMGT
MGI ID MGI:3606242
MGI Symbol Nostrin
EMBL AJ564264 AK052926 AL929221 AY280963 BC069942
GenPept AAH69942 AAP32311 BAC35204 CAD91927 CAM24122
RNA Seq Atlas 329416

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca