InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cnot8

Summary

InnateDB Protein

IDBP-176046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnot8

Protein Name

CCR4-NOT transcription complex, subunit 8

Synonyms

1500015I04Rik; 1810022F04Rik; AA536816; AU015770; AU043059;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020822

InnateDB Gene

IDBG-176044 (Cnot8)

Protein Structure

UniProt Annotation

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269PubMed:22367759}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004535	poly(A)-specific ribonuclease activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0031047	gene silencing by RNA
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic