InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asna1

Summary

InnateDB Protein

IDBP-176098.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asna1

Protein Name

arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

Synonyms

1810048H22Rik; ArsA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065337

InnateDB Gene

IDBG-176096 (Asna1)

Protein Structure

UniProt Annotation

Function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. {ECO:0000255HAMAP- Rule:MF_03112}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03112}. Endoplasmic reticulum {ECO:0000255HAMAP-Rule:MF_03112}. Nucleus, nucleolus {ECO:0000255HAMAP-Rule:MF_03112}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0046872	metal ion binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0045048	protein insertion into ER membrane

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005783	endoplasmic reticulum
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1928379

InterPro

IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain
IPR016300 Arsenical pump ATPase, ArsA/GET3
IPR025723 Anion-transporting ATPase-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01656
PF02374

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O54984

PhosphoSite