InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abcb11

Summary

InnateDB Protein

IDBP-176112.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abcb11

Protein Name

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Synonyms

ABC16; Bsep; Lith1; PFIC2; PGY4; SPGP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099771

InnateDB Gene

IDBG-176110 (Abcb11)

Protein Structure

UniProt Annotation

Function

Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0015126	canalicular bile acid transmembrane transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015722	canalicular bile acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045177	apical part of cell
GO:0046581	intercellular canaliculus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1351619

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QY30