InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp4a14

Summary

InnateDB Protein

IDBP-176151.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp4a14

Protein Name

cytochrome P450, family 4, subfamily a, polypeptide 14

Synonyms

AI314743;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030487

InnateDB Gene

IDBG-176149 (Cyp4a14)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. {ECO:0000305}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Very low level in liver, kidney and spleen. {ECO:0000269PubMed:9271096}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005504	fatty acid binding
GO:0005506	iron ion binding
GO:0008391	arachidonic acid monooxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685	alkane 1-monooxygenase activity
GO:0020037	heme binding
GO:0050544	arachidonic acid binding
GO:0052869	arachidonic acid omega-hydroxylase activity

Biological Process

GO:0001822	kidney development
GO:0009725	response to hormone
GO:0042493	response to drug
GO:0043651	linoleic acid metabolic process
GO:0046456	icosanoid biosynthetic process
GO:0048252	lauric acid metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1096550

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35728