InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clic1

Summary

InnateDB Protein

IDBP-176249.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clic1

Protein Name

chloride intracellular channel 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000007257

InnateDB Gene

IDBG-176247 (Clic1)

Protein Structure

UniProt Annotation

Function

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Mostly in the nucleus including in the nuclear membrane. Small amount in the cytoplasm and the plasma membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006821	chloride transport
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0045669	positive regulation of osteoblast differentiation
GO:0051881	regulation of mitochondrial membrane potential
GO:1902476	chloride transmembrane transport

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0034707	chloride channel complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle