Version 5.4
Mus musculus Gene: Clic1
Summary
InnateDB Gene IDBG-176247.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clic1
Gene Name chloride intracellular channel 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000007041
Encoded Proteins
IDBP-176249
chloride intracellular channel 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213719:
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35049966-35058749
Strand Forward strand
Band B1
Transcripts
ENSMUST00000007257 ENSMUSP00000007257
ENSMUST00000172599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006821 chloride transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0045669 positive regulation of osteoblast differentiation
GO:0051881 regulation of mitochondrial membrane potential
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0034707 chloride channel complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000213719
View Gene Order
ENSBTAG00000013533
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.29524
RefSeq NM_033444
OMIM
CCDS CCDS28675
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca