InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Polr3c

Summary

InnateDB Protein

IDBP-176297.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Polr3c

Protein Name

polymerase (RNA) III (DNA directed) polypeptide C

Synonyms

4933407E01Rik; RPC3; RPC62;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029741

InnateDB Gene

IDBG-176295 (Polr3c)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB- DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001056	RNA polymerase III activity
GO:0003677	DNA binding
GO:0003899	DNA-directed RNA polymerase activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006383	transcription from RNA polymerase III promoter
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0051607	defense response to virus