Version 5.4
Homo sapiens Protein: MED15
Summary
InnateDB Protein IDBP-1763.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED15
Protein Name mediator complex subunit 15
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000372434
InnateDB Gene IDBG-1757 (MED15)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269PubMed:12167862, ECO:0000269PubMed:16630888, ECO:0000269PubMed:16799563}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney. {ECO:0000269PubMed:11024300}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0005515 protein binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR019087 Mediator complex, subunit Med15, metazoa
PFAM PF09606
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96RN5
PhosphoSite PhosphoSite-Q96RN5
TrEMBL Q69YK5
UniProt Splice Variant
Entrez Gene 51586
UniGene Hs.517421
RefSeq NP_001280165
HUGO HGNC:14248
OMIM 607372
CCDS CCDS74824
HPRD 12117
IMGT
EMBL AC004033 AC005500 AC007050 AC007731 AF056191 AF328769 AK074268 AK090465 AK297284 AL832923 BC007529 BC013985 CH471176 CR456537 U80745
GenPept AAB91443 AAC12944 AAH07529 AAH13985 AAK58423 BAB85034 BAC03446 BAG59755 CAG30423 CAH10623 EAX02951 EAX02952 EAX02954 EAX02956

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca