InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ogg1

Summary

InnateDB Protein

IDBP-176303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ogg1

Protein Name

8-oxoguanine DNA-glycosylase 1

Synonyms

Mmh;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032406

InnateDB Gene

IDBG-176301 (Ogg1)

Protein Structure

UniProt Annotation

Function

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest expression in testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000702	oxidized base lesion DNA N-glycosylase activity
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0019104	DNA N-glycosylase activity
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0002526	acute inflammatory response
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0009314	response to radiation
GO:0032355	response to estradiol
GO:0033158	regulation of protein import into nucleus, translocation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045471	response to ethanol
GO:0051593	response to folic acid
GO:0071276	cellular response to cadmium ion