InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ogg1

Summary

InnateDB Gene

IDBG-176301.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ogg1

Gene Name

8-oxoguanine DNA-glycosylase 1

Synonyms

Mmh

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030271

Encoded Proteins

IDBP-176303

8-oxoguanine DNA-glycosylase 1

IDBP-535768

8-oxoguanine DNA-glycosylase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114026:
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:113326972-113335068

Strand

Forward strand

Band

Transcripts

ENSMUST00000032406	ENSMUSP00000032406
ENSMUST00000129871
ENSMUST00000136263
ENSMUST00000154350
ENSMUST00000147945	ENSMUSP00000116265

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000702	oxidized base lesion DNA N-glycosylase activity
GO:0003684	damaged DNA binding
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0008534	oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0019104	DNA N-glycosylase activity
GO:0034039	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0002526	acute inflammatory response
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006979	response to oxidative stress
GO:0007568	aging
GO:0009314	response to radiation
GO:0032355	response to estradiol
GO:0033158	regulation of protein import into nucleus, translocation
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0045471	response to ethanol
GO:0051593	response to folic acid
GO:0071276	cellular response to cadmium ion