InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sppl2b

Summary

InnateDB Protein

IDBP-176309.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sppl2b

Protein Name

RIKEN cDNA 3110056O03 gene

Synonyms

3110056O03Rik; AW550292; PSL1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036289

InnateDB Gene

IDBG-176307 (Sppl2b)

Protein Structure

UniProt Annotation

Function

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF- alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=targeted through the entire secretory pathway to endosomes/lysosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004190	aspartic-type endopeptidase activity
GO:0005515	protein binding
GO:0042500	aspartic endopeptidase activity, intramembrane cleaving
GO:0042803	protein homodimerization activity

Biological Process

GO:0006509	membrane protein ectodomain proteolysis
GO:0031293	membrane protein intracellular domain proteolysis
GO:0050776	regulation of immune response

Cellular Component

GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030660	Golgi-associated vesicle membrane
GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane