InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpr55

Summary

InnateDB Protein

IDBP-176331.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpr55

Protein Name

G protein-coupled receptor 55

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000084196

InnateDB Gene

IDBG-176329 (Gpr55)

Protein Structure

UniProt Annotation

Function

Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca(2+) release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA (By similarity). Putative cannabinoid receptor (By similarity). May play a role in bone physiology by regulating osteoclast number and function (By similarity). May be involved in hyperalgesia associated with inflammatory and neuropathic pain. {ECO:0000250, ECO:0000269PubMed:18502582}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004949	cannabinoid receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0035025	positive regulation of Rho protein signal transduction
GO:0038171	cannabinoid signaling pathway
GO:0045453	bone resorption
GO:0045671	negative regulation of osteoclast differentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade