InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tada3

Summary

InnateDB Protein

IDBP-176435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tada3

Protein Name

transcriptional adaptor 3

Synonyms

1110004B19Rik; ADA3; AI987856; Tada3l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032410

InnateDB Gene

IDBG-176433 (Tada3)

Protein Structure

UniProt Annotation

Function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019904	protein domain specific binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0010628	positive regulation of gene expression
GO:0031063	regulation of histone deacetylation
GO:0031647	regulation of protein stability
GO:0043966	histone H3 acetylation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090043	regulation of tubulin deacetylation

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex
GO:0030914	STAGA complex
GO:0033276	transcription factor TFTC complex
GO:0072686	mitotic spindle