InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Htr2b

Summary

InnateDB Protein

IDBP-176590.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr2b

Protein Name

5-hydroxytryptamine (serotonin) receptor 2B

Synonyms

5-HT2B; AJ012488; AV377389;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027431

InnateDB Gene

IDBG-176588 (Htr2b)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine. {ECO:0000269PubMed:10944220, ECO:0000269PubMed:11413089, ECO:0000269PubMed:12244304, ECO:0000269PubMed:12738797, ECO:0000269PubMed:1426253, ECO:0000269PubMed:16940156, ECO:0000269PubMed:17846081, ECO:0000269PubMed:18337424, ECO:0000269PubMed:19941613, ECO:0000269PubMed:23346101}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.

Disease Associations

Tissue Specificity

Ubiquitous. Detected in intestine, heart, skeletal muscle, testis, urinary bladder, stomach, liver, lung, brain and kidney. Detected in osteoblasts. Detected in the raphe nucleus in the brain, in dorsal root ganglion neurons, the brain stem, cerebellum and spinal cord. Detected in interstitial cells of Cajal in the small intestine. {ECO:0000269PubMed:10944220, ECO:0000269PubMed:1426253, ECO:0000269PubMed:17846081, ECO:0000269PubMed:18337424, ECO:0000269PubMed:19941613, ECO:0000269PubMed:21273425}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005099	Ras GTPase activator activity
GO:0005262	calcium channel activity
GO:0008144	drug binding
GO:0051378	serotonin binding

Biological Process

GO:0001755	neural crest cell migration
GO:0001819	positive regulation of cytokine production
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002031	G-protein coupled receptor internalization
GO:0003007	heart morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0006182	cGMP biosynthetic process
GO:0006874	cellular calcium ion homeostasis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007507	heart development
GO:0007610	behavior
GO:0008284	positive regulation of cell proliferation
GO:0010507	negative regulation of autophagy
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0014033	neural crest cell differentiation
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0014827	intestine smooth muscle contraction
GO:0016310	phosphorylation
GO:0019722	calcium-mediated signaling
GO:0032320	positive regulation of Ras GTPase activity
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0048598	embryonic morphogenesis
GO:0050715	positive regulation of cytokine secretion
GO:0050795	regulation of behavior
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051781	positive regulation of cell division
GO:0060548	negative regulation of cell death
GO:0070371	ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070528	protein kinase C signaling
GO:0070588	calcium ion transmembrane transport
GO:0071502	cellular response to temperature stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:109323

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000482 5-Hydroxytryptamine 2B receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00651
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q02152