InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Htr2b

Summary

InnateDB Gene

IDBG-176588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Htr2b

Gene Name

5-hydroxytryptamine (serotonin) receptor 2B

Synonyms

5-HT2B; AJ012488; AV377389

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026228

Encoded Proteins

IDBP-176590

5-hydroxytryptamine (serotonin) receptor 2B

IDBP-540954

5-hydroxytryptamine (serotonin) receptor 2B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135914:
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:86099026-86111970

Strand

Reverse strand

Band

Transcripts

ENSMUST00000027431	ENSMUSP00000027431
ENSMUST00000155077	ENSMUSP00000116273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005099	Ras GTPase activator activity
GO:0005262	calcium channel activity
GO:0008144	drug binding
GO:0051378	serotonin binding

Biological Process

GO:0001755	neural crest cell migration
GO:0001819	positive regulation of cytokine production
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002031	G-protein coupled receptor internalization
GO:0003007	heart morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0006182	cGMP biosynthetic process
GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007208	phospholipase C-activating serotonin receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007507	heart development
GO:0007610	behavior
GO:0008284	positive regulation of cell proliferation
GO:0010507	negative regulation of autophagy
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0014033	neural crest cell differentiation
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0014827	intestine smooth muscle contraction
GO:0016310	phosphorylation
GO:0019722	calcium-mediated signaling
GO:0032320	positive regulation of Ras GTPase activity
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0048598	embryonic morphogenesis
GO:0050715	positive regulation of cytokine secretion
GO:0050795	regulation of behavior
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051781	positive regulation of cell division
GO:0060548	negative regulation of cell death
GO:0070371	ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070528	protein kinase C signaling
GO:0070588	calcium ion transmembrane transport
GO:0071502	cellular response to temperature stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0043005	neuron projection
GO:0045202	synapse