InnateDB Protein
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IDBP-176602.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mtap1b
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Protein Name
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microtubule-associated protein 1B
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Synonyms
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A230055D22; AI843217; LC1; MAP5; Mtap-5; Mtap1b; Mtap5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068374
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InnateDB Gene
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IDBG-176600 (Mtap1b)
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Protein Structure
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Function |
Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation. {ECO:0000250, ECO:0000269PubMed:18075266, ECO:0000269PubMed:21984824}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000305PubMed:21984824}. Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000269PubMed:21984824}. Cell projection, dendritic spine {ECO:0000269PubMed:21984824}. Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated |
Total |
20
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
0
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Protein-RNA |
2
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
43 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1306778
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InterPro |
IPR000102
Neuraxin/MAP1B repeat
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PFAM |
PF00414
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P14873
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PhosphoSite |
PhosphoSite-P14873
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TrEMBL |
Q8CAI9
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UniProt Splice Variant |
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Entrez Gene |
17755
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UniGene |
Mm.474896
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RefSeq |
NP_032660
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MGI ID |
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MGI Symbol |
Map1b
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OMIM |
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CCDS |
CCDS26723
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HPRD |
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IMGT |
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EMBL |
AC170188
AK038690
AK148870
AK158307
X51396
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GenPept |
BAC30100
BAE28683
BAE34454
CAA35761
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