InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mtap1b

Summary

InnateDB Gene

IDBG-176600.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtap1b

Gene Name

microtubule-associated protein 1B

Synonyms

A230055D22; AI843217; LC1; MAP5; Mtap-5; Mtap1b; Mtap5

Species

Mus musculus

Ensembl Gene

ENSMUSG00000052727

Encoded Proteins

IDBP-176602

microtubule-associated protein 1B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131711:
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:99421464-99516602

Strand

Reverse strand

Band

Transcripts

ENSMUST00000064762

ENSMUSP00000068374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	2 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005519	cytoskeletal regulatory protein binding
GO:0008017	microtubule binding
GO:0016787	hydrolase activity

Biological Process

GO:0001578	microtubule bundle formation
GO:0007017	microtubule-based process
GO:0007409	axonogenesis
GO:0008152	metabolic process
GO:0009987	cellular process
GO:0016358	dendrite development
GO:0032387	negative regulation of intracellular transport
GO:0045773	positive regulation of axon extension
GO:0047497	mitochondrion transport along microtubule
GO:0048675	axon extension
GO:0061162	establishment of monopolar cell polarity

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0043197	dendritic spine
GO:0045202	synapse

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000131711

View Gene Order

ENSBTAG00000001961

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

reelinpathway

Reelin signaling pathway

netrin_pathway

Netrin-mediated signaling events

lis1pathway

Lissencephaly gene (LIS1) in neuronal migration and development

Cross-References

SwissProt

P14873

TrEMBL

Q3TYV8 Q3UF78 Q8CAI9

UniProt Splice Variant

Entrez Gene

17755

UniGene

Mm.409176 Mm.414384 Mm.4173 Mm.468951 Mm.474896

RefSeq

NM_008634 XM_006517548

OMIM

CCDS

CCDS26723

HPRD

IMGT

MGI ID

MGI:1306778

MGI Symbol

Map1b

EMBL

AC170188 AK038690 AK148870 AK158307 X51396

GenPept

BAC30100 BAE28683 BAE34454 CAA35761

RNA Seq Atlas

17755