InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Yaf2

Summary

InnateDB Protein

IDBP-176636.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Yaf2

Protein Name

YY1 associated factor 2

Synonyms

2810021M11Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079179

InnateDB Gene

IDBG-176634 (Yaf2)

Protein Structure

UniProt Annotation

Function

Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14557078}.

Disease Associations

Tissue Specificity

In the mesoderm, expressed in the region close to the surface ectoderm. {ECO:0000269PubMed:14557078}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated