Version 5.4
Mus musculus Gene: Yaf2
Summary
InnateDB Gene IDBG-176634.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Yaf2
Gene Name YY1 associated factor 2
Synonyms 2810021M11Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000022634
Encoded Proteins
IDBP-176636
YY1 associated factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000015153:
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:93284278-93336935
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000080299 ENSMUSP00000079179
ENSMUST00000133736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000015153
View Gene Order
ENSBTAG00000015025
Not yet available
Cross-References
SwissProt Q99LW6
TrEMBL
UniProt Splice Variant
Entrez Gene 67057
UniGene Mm.4714 Mm.472406
RefSeq NM_024189
OMIM
CCDS CCDS27765
HPRD
IMGT
MGI ID MGI:1914307
MGI Symbol Yaf2
EMBL AB100452 AB100453 AK005008 AK148634 BC002192
GenPept AAH02192 BAB23741 BAC97817 BAC97818 BAE28627
RNA Seq Atlas 67057

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca