Version 5.4
Mus musculus Protein: Gja8
Summary
InnateDB Protein IDBP-176664.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gja8
Protein Name gap junction protein, alpha 8
Synonyms Aey5; Cnx50; Cx50; Lop10;
Species Mus musculus
Ensembl Protein ENSMUSP00000049532
InnateDB Gene IDBG-176662 (Gja8)
Protein Structure
UniProt Annotation
Function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Disease Associations
Tissue Specificity Eye lens.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005243 gap junction channel activity
GO:0005515 protein binding
Biological Process
GO:0002088 lens development in camera-type eye
GO:0007154 cell communication
GO:0007267 cell-cell signaling
GO:0043010 camera-type eye development
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005922 connexon complex
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:99953
InterPro IPR000500 Connexin
IPR002266 Gap junction alpha-8 protein (Cx50)
IPR013092 Connexin, N-terminal
IPR019570 Gap junction protein, cysteine-rich domain
PFAM PF03509
PF00029
PF10582
PRINTS PR00206
PR01137
PIRSF
SMART SM00037
SM01089
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28236
PhosphoSite PhosphoSite-
TrEMBL Q548M7
UniProt Splice Variant
Entrez Gene 14616
UniGene Mm.468160
RefSeq NP_032149
MGI ID
MGI Symbol Gja8
OMIM
CCDS CCDS17651
HPRD
IMGT
EMBL AF304357 AF321120 BC120513 BC125569 CH466620 GU363513 GU363514 GU363515 M91243
GenPept AAA37497 AAG42241 AAG59880 AAI20514 AAI25570 ADC38984 ADC38985 ADC38986 EDL38928

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca