InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itsn1

Summary

InnateDB Protein

IDBP-176674.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itsn1

Protein Name

intersectin 1 (SH3 domain protein 1A)

Synonyms

AA517634; AA545208; AI316805; AI839402; AI848451; Ehsh1; Ese1; Itsn; Sh3p17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000056011

InnateDB Gene

IDBG-176668 (Itsn1)

Protein Structure

UniProt Annotation

Function

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Inhibits ARHGAP31 activity toward RAC1. Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase. {ECO:0000269PubMed:20585582}.

Subcellular Localization

Endomembrane system {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Colocalizes with SGIP1 at the plasma membrane in structures corresponding most problably to clathrin-coated pits. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at high levels in brain, heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019209	kinase activator activity
GO:0032947	protein complex scaffold
GO:0070064	proline-rich region binding

Biological Process

GO:0006897	endocytosis
GO:0007264	small GTPase mediated signal transduction
GO:0032319	regulation of Rho GTPase activity
GO:0042327	positive regulation of phosphorylation
GO:0043524	negative regulation of neuron apoptotic process
GO:0051897	positive regulation of protein kinase B signaling

Cellular Component

GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0030027	lamellipodium
GO:0030054	cell junction
GO:0030139	endocytic vesicle
GO:0043005	neuron projection
GO:0045202	synapse