InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gja5

Summary

InnateDB Protein

IDBP-176711.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gja5

Protein Name

gap junction protein, alpha 5

Synonyms

5730555N10Rik; Cnx40; Cx40; Gja-5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088264

InnateDB Gene

IDBG-176709 (Gja5)

Protein Structure

UniProt Annotation

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Disease Associations

Tissue Specificity

Kidney, heart and skin, but most abundant in lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005243	gap junction channel activity
GO:0055077	gap junction hemi-channel activity
GO:0071253	connexin binding
GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling
GO:0086077	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling

Biological Process

GO:0001501	skeletal system development
GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0003071	renal system process involved in regulation of systemic arterial blood pressure
GO:0003073	regulation of systemic arterial blood pressure
GO:0003105	negative regulation of glomerular filtration
GO:0003151	outflow tract morphogenesis
GO:0003158	endothelium development
GO:0003161	cardiac conduction system development
GO:0003174	mitral valve development
GO:0003193	pulmonary valve formation
GO:0003281	ventricular septum development
GO:0003283	atrial septum development
GO:0003284	septum primum development
GO:0003294	atrial ventricular junction remodeling
GO:0006813	potassium ion transport
GO:0007507	heart development
GO:0010643	cell communication by chemical coupling
GO:0010644	cell communication by electrical coupling
GO:0010652	positive regulation of cell communication by chemical coupling
GO:0016264	gap junction assembly
GO:0030326	embryonic limb morphogenesis
GO:0035050	embryonic heart tube development
GO:0035922	foramen ovale closure
GO:0042312	regulation of vasodilation
GO:0045776	negative regulation of blood pressure
GO:0045907	positive regulation of vasoconstriction
GO:0045909	positive regulation of vasodilation
GO:0048844	artery morphogenesis
GO:0051259	protein oligomerization
GO:0055085	transmembrane transport
GO:0055117	regulation of cardiac muscle contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060412	ventricular septum morphogenesis
GO:0060413	atrial septum morphogenesis
GO:0061337	cardiac conduction
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086014	atrial cardiac muscle cell action potential
GO:0086015	SA node cell action potential
GO:0086053	AV node cell to bundle of His cell communication by electrical coupling
GO:0086064	cell communication by electrical coupling involved in cardiac conduction
GO:0086065	cell communication involved in cardiac conduction
GO:0086067	AV node cell to bundle of His cell communication
GO:0086069	bundle of His cell to Purkinje myocyte communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:1900133	regulation of renin secretion into blood stream
GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential
GO:1990029	vasomotion