Version 5.4
Mus musculus Gene: Gja5
Summary
InnateDB Gene IDBG-176709.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gja5
Gene Name gap junction protein, alpha 5
Synonyms 5730555N10Rik; Cnx40; Cx40; Gja-5
Species Mus musculus
Ensembl Gene ENSMUSG00000057123
Encoded Proteins
IDBP-176711
gap junction protein, alpha 5
IDBP-538343
gap junction protein, alpha 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog null:
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:97032416-97053634
Strand Forward strand
Band F2.1
Transcripts
ENSMUST00000072600 ENSMUSP00000088264
ENSMUST00000132256 ENSMUSP00000123582
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005243 gap junction channel activity
GO:0055077 gap junction hemi-channel activity
GO:0071253 connexin binding
GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling
GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
Biological Process
GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
GO:0003073 regulation of systemic arterial blood pressure
GO:0003105 negative regulation of glomerular filtration
GO:0003151 outflow tract morphogenesis
GO:0003158 endothelium development
GO:0003161 cardiac conduction system development
GO:0003174 mitral valve development
GO:0003193 pulmonary valve formation
GO:0003281 ventricular septum development
GO:0003283 atrial septum development
GO:0003284 septum primum development
GO:0003294 atrial ventricular junction remodeling
GO:0006813 potassium ion transport
GO:0007507 heart development
GO:0010643 cell communication by chemical coupling
GO:0010644 cell communication by electrical coupling
GO:0010652 positive regulation of cell communication by chemical coupling
GO:0016264 gap junction assembly
GO:0030326 embryonic limb morphogenesis
GO:0035050 embryonic heart tube development
GO:0035922 foramen ovale closure
GO:0042312 regulation of vasodilation
GO:0045776 negative regulation of blood pressure
GO:0045907 positive regulation of vasoconstriction
GO:0045909 positive regulation of vasodilation
GO:0048844 artery morphogenesis
GO:0051259 protein oligomerization
GO:0055085 transmembrane transport
GO:0055117 regulation of cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0061337 cardiac conduction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086014 atrial cardiac muscle cell action potential
GO:0086015 SA node cell action potential
GO:0086053 AV node cell to bundle of His cell communication by electrical coupling
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
GO:0086065 cell communication involved in cardiac conduction
GO:0086067 AV node cell to bundle of His cell communication
GO:0086069 bundle of His cell to Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:1900133 regulation of renin secretion into blood stream
GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential
GO:1990029 vasomotion
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0005921 gap junction
GO:0005922 connexon complex
GO:0014704 intercalated disc
GO:0042995 cell projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
null
View Gene Order
ENSBTAG00000006720
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001271628 NM_008121
OMIM
CCDS CCDS17652
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca