Version 5.4
| Mus musculus Protein: Lim2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-176794.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Lim2 | ||||||||
| Protein Name | lens intrinsic membrane protein 2 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000004732 | ||||||||
| InnateDB Gene | IDBG-176792 (Lim2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. | ||||||||
| Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | Note=Defects in Lim2 are the cause of the cataractous mouse mutant with total opacity of lens 3 (To3). Mice heterozygous or homozygous for the To3 mutation have total opacity of the lens with a dense cataract. In addition, the To3/To3 homozygotes exhibit microphthalmia, abnormally small eyes. | ||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:104698 | ||||||||
| InterPro |
IPR003935
Lens fibre membrane intrinsic protein IPR004031 PMP-22/EMP/MP20/Claudin superfamily IPR004032 PMP-22/EMP/MP20 |
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| PFAM |
PF00822
PF13903 |
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| PRINTS |
PR01457
PR01453 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P56563 | ||||||||
| PhosphoSite | PhosphoSite-P56563 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 233187 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_808361 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Lim2 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS21168 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF320075 AK029354 AK164958 BC119253 BC119255 | ||||||||
| GenPept | AAI19254 AAI19256 AAK08062 BAC26414 BAE37979 | ||||||||