InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adam28

Summary

InnateDB Protein

IDBP-176816.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adam28

Protein Name

a disintegrin and metallopeptidase domain 28

Synonyms

C130072N01Rik; D430033C21Rik; Dtgn1; eMDCII; MDC-L; MDC-Lm; MDC-Ls; MDCL; TECADAM;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022642

InnateDB Gene

IDBG-176814 (Adam28)

Protein Structure

UniProt Annotation

Function

May play a role in organogenesis and organ-specific functions such as thymic T-cell development.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Strong expression in thymic epithelial cells and developmentally related tissues including the trachea, thyroid, lung and stomach, but not in lymphocytes. Expressed at high levels also in epididymis. In contrast with human is not expressed in immature or mature lymphocyte populations of thymocytes, lymph node, spleen, and bone marrow. {ECO:0000269PubMed:11867223}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508

proteolysis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:105988

InterPro

IPR000742 Epidermal growth factor-like domain
IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich

PFAM

PF00008
PF01421
PF00200
PF01562
PF08516

PRINTS

PR00289

PIRSF

SMART

SM00181
SM00050
SM00608

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt