InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bag6

Summary

InnateDB Protein

IDBP-176821.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bag6

Protein Name

BCL2-associated athanogene 6

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025250

InnateDB Gene

IDBG-176819 (Bag6)

Protein Structure

UniProt Annotation

Function

Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Acts in part by regulating stability of proteins and their degradation by the proteasome. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane (By similarity). Participates in endoplasmic reticulum stress- induced apoptosis via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2. Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. {ECO:0000250}.Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).Can be released from tumor and dendritic cells in membrane vesicles or exosomes, and engage NCR3 thereby promoting natural killer cell (NK) activation and cytotoxicity. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:18056262}. Nucleus {ECO:0000250}. Note=The C- terminal fragment generated by caspase-3 is cytoplasmic. Also found in extracellular vesicular exosomes in some tumor cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 119 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	119 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0031593	polyubiquitin binding
GO:0043022	ribosome binding
GO:0070628	proteasome binding

Biological Process

GO:0001822	kidney development
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006810	transport
GO:0006915	apoptotic process
GO:0007130	synaptonemal complex assembly
GO:0007283	spermatogenesis
GO:0007420	brain development
GO:0009790	embryo development
GO:0016568	chromatin modification
GO:0018393	internal peptidyl-lysine acetylation
GO:0030154	cell differentiation
GO:0030324	lung development
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042127	regulation of cell proliferation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045861	negative regulation of proteolysis
GO:0050821	protein stabilization
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071816	tail-anchored membrane protein insertion into ER membrane